除草酸，一种来自海绵植物草本海绵的5,5,5-三氯亮氨酸代谢产物的简单原型。

Herbacic acid, a simple prototype of 5,5,5-trichloroleucine metabolites from the sponge Dysidea herbacea.

作者信息

MacMillan J B, Molinski T F

机构信息

Department of Chemistry, University of California, Davis, California 95616, USA.

出版信息

J Nat Prod. 2000 Jan;63(1):155-7. doi: 10.1021/np990468j.

DOI:10.1021/np990468j

PMID:10650102

Abstract

Dysidea herbacea, collected at Harrier Reef on the Great Barrier Reef, contains the novel metabolite herbacic acid as the major trichloroleucine metabolite. Herbacic acid appears to be an early product of direct free-radical chlorination of leucine and is a prototype for further transformation of the free carboxylic acid group and generation of complex trichloromethyl metabolites, including natural products of the dysidenin family.

摘要

从大堡礁的哈里尔礁采集的草本海绵（Dysidea herbacea）含有新型代谢产物草本酸，它是主要的三氯亮氨酸代谢产物。草本酸似乎是亮氨酸直接自由基氯化的早期产物，并且是游离羧酸基团进一步转化以及生成复杂的三氯甲基代谢产物（包括苔藓抑素家族的天然产物）的原型。