Handayani D, Edrada R A, Proksch P, Wray V, Witte L, Van Soest R W, Kunzmann A
Julius-von-Sachs Institut fur Biowissenschaften, Lehrstuhl fur Pharmazeutische Biologie, Wurzburg, Germany.
J Nat Prod. 1997 Dec;60(12):1313-6. doi: 10.1021/np970271w.
The marine sponge Dysidea herbacea collected from Indonesia yielded four new polybrominated diphenyl ether congeners 2-5 and the known derivatives 1, 6, and 7. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long-range 13C-1H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the Gram-positive bacteria Bacillus subtilis and the phytopathogenic fungus Cladosporium cucumerinum. The isolated polybrominated compounds were also active in the brine shrimp lethality test. In the latter bioassay, compounds 1 and 6 were the most active with LC50's of 0.96 [SE +/- 0.19] and 0.94 [SE +/- 0.70] microg/mL, respectively.
从印度尼西亚采集的海洋海绵药海绵（Dysidea herbacea）产生了四种新的多溴二苯醚同系物2 - 5以及已知的衍生物1、6和7。基于核磁共振光谱（1H、13C、COSY、1H检测的直接和远程13C - 1H相关性）和质谱（EIMS）数据明确确定了新化合物的结构。所有化合物对革兰氏阳性细菌枯草芽孢杆菌和植物病原真菌黄瓜枝孢均有活性。分离出的多溴化合物在卤虫致死试验中也有活性。在后一种生物测定中，化合物1和6活性最高，LC50分别为0.96 [标准误±0.19]和0.94 [标准误±0.70]微克/毫升。
