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神经甾体3α-雄甾二醇可预防大鼠肾上腺切除术后齿状回颗粒层出现的抑制性回避缺陷和固缩细胞。

The neurosteroid, 3alpha-androstanediol, prevents inhibitory avoidance deficits and pyknotic cells in the granule layer of the dentate gyrus induced by adrenalectomy in rats.

作者信息

Frye C A, McCormick C M

机构信息

Psychology Department, The University at Albany-SUNY, Albany, NY 12222, USA.

出版信息

Brain Res. 2000 Feb 7;855(1):166-70. doi: 10.1016/s0006-8993(99)02208-8.

DOI:10.1016/s0006-8993(99)02208-8
PMID:10650145
Abstract

Testosterone (T), dihydrotestosterone (DHT), 3alpha-diol (5alpha-androstane-3alpha,17beta-diol), or vehicle was administered daily to gonadectomized, adrenalectomized male Long-Evans rats. Four days after adrenalectomy (ADX), animals were tested for inhibitory avoidance. Vehicle-treated rats had shorter latencies than 3alpha-diol-treated rats and non-corticosterone-depleted rats. All three androgens significantly reduced the number of pyknotic cells in corticosterone-depleted rats. Neurosteroids may mediate androgens' functional and morphological neuroprotective effects.

摘要

将睾酮（T）、双氢睾酮（DHT）、3α-二醇（5α-雄烷-3α,17β-二醇）或赋形剂每日给予去势、肾上腺切除的雄性Long-Evans大鼠。肾上腺切除（ADX）后四天，对动物进行抑制性回避测试。赋形剂处理的大鼠比3α-二醇处理的大鼠和未耗尽皮质酮的大鼠潜伏期更短。所有三种雄激素均显著减少了皮质酮耗尽大鼠中固缩细胞的数量。神经甾体可能介导雄激素的功能和形态学神经保护作用。

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