Georgatos S D, Theodoropoulos P A
Dept. of Basic Sciences, University of Crete, School of Medicine, Heraklion, Greece.
Crit Rev Eukaryot Gene Expr. 1999;9(3-4):373-81. doi: 10.1615/critreveukargeneexpr.v9.i3-4.220.
In higher eukaryotic cells the nuclear envelope is reversibly disassembled during mitosis. Under in vivo conditions this process occurs in a sequential, stepwise fashion and involves a variety of structural intermediates. Here we discuss the topological features of these intermediates and their transient interactions with chromatin and the cytoskeleton. As it becomes apparent, nuclear envelope disassembly and reassembly are regulated at multiple levels by modulating the affinity of protein-protein interactions, limiting the availability of structural subunits in different areas of the mitotic cytoplasm, and redirecting mechanical forces exerted by the microtubules.
在高等真核细胞中，核膜在有丝分裂期间会可逆地解体。在体内条件下，这个过程以连续、逐步的方式发生，涉及多种结构中间体。在这里，我们讨论这些中间体的拓扑特征以及它们与染色质和细胞骨架的瞬时相互作用。显而易见的是，核膜的解体和重新组装在多个层面受到调控，包括调节蛋白质 - 蛋白质相互作用的亲和力、限制有丝分裂细胞质不同区域结构亚基的可用性，以及重新引导微管施加的机械力。
