神经毒素损伤下橄榄核后大鼠的代偿性恢复过程及操作性反射

Compensatory restorative processes and operant reflexes in rats after neurotoxin lesioning of the inferior olive.

作者信息

Fanardzhyan V V, Oganesyan E A, Melik-Musyan A B, Papoyan E V, Govorkyan O V

机构信息

Laboratory for Central Nervous System Physiology, L. A. Orbel' Institute of Physiology, Armenian National Academy of Sciences, Erevan.

出版信息

Neurosci Behav Physiol. 1999 Nov-Dec;29(6):657-63. doi: 10.1007/BF02462480.

DOI:10.1007/BF02462480

PMID:10651322

Abstract

Studies on rats showed that complete neurotoxin lesioning of the inferior olive obviated the possibility of developing and restoring previously learned operant balance reflexes. Motor deficit and compensatory-restorative processes in rats treated with 3-acetylpyridine and high section of the dorsolateral funiculus of the spinal cord depended directly on the level of disruption of the inferior olive. Prolonged observation of rats with incomplete lesions to the inferior olive revealed improvements in the compensation of motor lesions and stabilization of operant reflexes.

摘要

对大鼠的研究表明，下橄榄核的完全神经毒素损伤消除了发展和恢复先前习得的操作性平衡反射的可能性。用3-乙酰吡啶处理的大鼠以及脊髓背外侧索高位横断后的运动缺陷和代偿-恢复过程直接取决于下橄榄核的破坏程度。对下橄榄核不完全损伤的大鼠进行长期观察发现，运动损伤的代偿有所改善，操作性反射也趋于稳定。