暴露于诊断性X射线与年龄相关性眼病发病情况
Exposure to diagnostic x-rays and incident age-related eye disease.
作者信息
Klein B E, Klein R E, Moss S E
机构信息
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53705-2397, USA.
出版信息
Ophthalmic Epidemiol. 2000 Mar;7(1):61-5.
OBJECTIVE
The purpose of this study was to evaluate whether a self-reported history of computed tomography or other x-rays of the head were associated with the incidence of age-related cataracts and maculopathy five years later.
METHOD
A 5-year longitudinal follow-up of the Beaver Dam Eye Study cohort (n=3,684, 43-86 years at baseline).
RESULTS
There was no evidence of a relationship between the x-ray exposures and the incidence of nuclear or cortical cataracts, or early maculopathy. There was a significant relationship to the incidence of posterior subcapsular cataract after adjusting for age only.
CONCLUSIONS
Adult patients in whom medical conditions warrant diagnostic x-rays of the head appear to be at little or no increased risk of age-related cataract or maculopathy. However, research efforts with more precise measures of x-ray exposure, longer follow-up, and further attempts to define uncontrolled confounders are warranted.
目的
本研究旨在评估自我报告的头部计算机断层扫描或其他X线检查史是否与五年后年龄相关性白内障和黄斑病变的发生率相关。
方法
对比弗迪姆眼研究队列进行为期5年的纵向随访（n = 3684，基线年龄43 - 86岁）。
结果
没有证据表明X线暴露与核性或皮质性白内障、或早期黄斑病变的发生率之间存在关联。仅在调整年龄后，与后囊下白内障的发生率存在显著关联。
结论
因医疗状况需要进行头部诊断性X线检查的成年患者，年龄相关性白内障或黄斑病变的风险似乎几乎没有增加或没有增加。然而，有必要进行研究，采用更精确的X线暴露测量方法、更长的随访时间，并进一步尝试确定未控制的混杂因素。
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