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Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.

作者信息

Abbenante G, Kovacs D M, Leung D L, Craik D J, Tanzi R E, Fairlie D P

机构信息

Centre for Drug Design and Development, University of Queensland, Brisbane, Queensland, 4072, Australia.

出版信息

Biochem Biophys Res Commun. 2000 Feb 5;268(1):133-5. doi: 10.1006/bbrc.2000.2098.

DOI:10.1006/bbrc.2000.2098
PMID:10652226
Abstract

A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most potent (IC(50) = 700 nM) in the series displaying an inhibitory profile which is different from reported inhibitors of beta-amyloid formation.

摘要

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