Dunn MJ
Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College School of Medicine, Heart Science Centre, Harefield Hospital, Harefield, Middlesex, UK UB9 6JH.
Drug Discov Today. 2000 Feb;5(2):76-84. doi: 10.1016/s1359-6446(99)01449-x.
The pathogenic mechanisms underlying cardiac dysfunction in heart disease are still largely unknown. It is likely, though, that significant alterations in myocardial gene and protein expression underlie these disease processes and determine their progression and outcome. Most molecular studies of cardiac dysfunction have been carried out on specific cellular systems. However, the application of the proteomic approach to the study of heart disease has made it possible to characterize global alterations in protein expression. This promises new insights into the cellular mechanisms involved in cardiac dysfunction and is likely to result in the discovery of novel diagnostic markers and new therapeutic opportunities.
心脏病中心脏功能障碍的致病机制在很大程度上仍不清楚。不过，心肌基因和蛋白质表达的显著改变很可能是这些疾病过程的基础，并决定其进展和结果。大多数关于心脏功能障碍的分子研究都是在特定的细胞系统上进行的。然而，蛋白质组学方法在心脏病研究中的应用使得表征蛋白质表达的整体变化成为可能。这有望为心脏功能障碍所涉及的细胞机制提供新的见解，并可能导致发现新的诊断标志物和新的治疗机会。
