McGregor Emma, Dunn Michael J
Proteome Sciences plc, Kings College, University of London, London SE5 8AF, UK.
Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R135-44. doi: 10.1093/hmg/ddg278. Epub 2003 Aug 19.
Heart diseases resulting in heart failure are among the leading causes of morbidity and mortality in developed countries. The underlying molecular causes of cardiac dysfunction in most heart diseases are still largely unknown, but are likely to result from underlying alterations in gene and protein expression. Proteomics now allows us to examine global alterations in protein expression in the diseased heart and will provide new insights into cellular mechanisms involved in cardiac dysfunction and should also result in the generation of new diagnostic and therapeutic markers. In this article we review the current status of proteomic technologies and describe how these are being applied to studies of human heart disease.
导致心力衰竭的心脏病是发达国家发病和死亡的主要原因之一。大多数心脏病中心脏功能障碍的潜在分子原因在很大程度上仍不清楚，但可能是基因和蛋白质表达的潜在改变所致。蛋白质组学现在使我们能够研究患病心脏中蛋白质表达的整体变化，将为参与心脏功能障碍的细胞机制提供新的见解，还应能产生新的诊断和治疗标志物。在本文中，我们综述了蛋白质组学技术的现状，并描述了这些技术如何应用于人类心脏病的研究。
