类风湿性关节炎与p53：氧化应激如何改变炎症性疾病的病程。
Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases.
作者信息
Tak P P, Zvaifler N J, Green D R, Firestein G S
机构信息
Division of Clinical Immunology and Rheumatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
出版信息
Immunol Today. 2000 Feb;21(2):78-82. doi: 10.1016/s0167-5699(99)01552-2.
Abstract
Oxidative stress at sites of chronic inflammation can cause permanent genetic changes. The development of mutations in the p53 tumor suppressor gene and other key regulatory genes could help convert inflammation into chronic disease in rheumatoid arthritis and other inflammatory disorders.
摘要
慢性炎症部位的氧化应激可导致永久性基因改变。p53肿瘤抑制基因和其他关键调控基因发生突变，可能促使类风湿关节炎和其他炎症性疾病中的炎症转变为慢性病。
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