• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

类风湿性关节炎与p53：氧化应激如何改变炎症性疾病的病程。

Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases.

作者信息

Tak P P, Zvaifler N J, Green D R, Firestein G S

机构信息

Division of Clinical Immunology and Rheumatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

出版信息

Immunol Today. 2000 Feb;21(2):78-82. doi: 10.1016/s0167-5699(99)01552-2.

DOI:10.1016/s0167-5699(99)01552-2
PMID:10652465
Abstract

Oxidative stress at sites of chronic inflammation can cause permanent genetic changes. The development of mutations in the p53 tumor suppressor gene and other key regulatory genes could help convert inflammation into chronic disease in rheumatoid arthritis and other inflammatory disorders.

摘要

慢性炎症部位的氧化应激可导致永久性基因改变。p53肿瘤抑制基因和其他关键调控基因发生突变，可能促使类风湿关节炎和其他炎症性疾病中的炎症转变为慢性病。

相似文献

1
Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases.类风湿性关节炎与p53：氧化应激如何改变炎症性疾病的病程。
Immunol Today. 2000 Feb;21(2):78-82. doi: 10.1016/s0167-5699(99)01552-2.
2
Expression of p53 protein in rheumatoid arthritis synovium. An immunohistochemical analysis.类风湿关节炎滑膜中p53蛋白的表达。一项免疫组织化学分析。
Korean J Intern Med. 1999 Jan;14(1):59-65. doi: 10.3904/kjim.1999.14.1.59.
3
Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium.类风湿关节炎滑膜中p53肿瘤抑制基因体细胞突变的分析
Rheumatology (Oxford). 2000 Mar;39(3):262-6. doi: 10.1093/rheumatology/39.3.262.
4
The p53 status in juvenile chronic arthritis and rheumatoid arthritis.青少年慢性关节炎和类风湿性关节炎中的p53状态
Clin Exp Immunol. 2000 Nov;122(2):264-9. doi: 10.1046/j.1365-2249.2000.01358.x.
5
Study of P53 in peripheral blood and synovial mononuclear cells of rheumatoid arthritis and osteoarthritis patients and its relation to the degree of disease activity.类风湿关节炎和骨关节炎患者外周血及滑膜单个核细胞中P53的研究及其与疾病活动度的关系。
Egypt J Immunol. 2005;12(2):61-70.
6
p53 in fibroblast-like synoviocytes can regulate T helper cell functions in patients with active rheumatoid arthritis.成纤维样滑膜细胞中的 p53 可调节活动期类风湿关节炎患者的辅助性 T 细胞功能。
Chin Med J (Engl). 2011 Feb;124(3):364-8.
7
CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells.细胞毒性T淋巴细胞相关抗原4免疫球蛋白（CTLA-4IG）通过防止滑膜黏附细胞诱导的Rap1失活来抑制活性氧，Rap1是类风湿性关节炎T细胞中氧化应激的一种Ras家族GTP酶介质。
Arthritis Rheum. 2006 Oct;54(10):3135-43. doi: 10.1002/art.22139.
8
Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium.类风湿关节炎中的细胞凋亡：类风湿关节炎滑膜中p53的过表达。
Am J Pathol. 1996 Dec;149(6):2143-51.
9
p53, proto-oncogene and rheumatoid arthritis.
Semin Arthritis Rheum. 2002 Apr;31(5):299-310. doi: 10.1053/sarh.2002.31550.
10
p53 expression in rheumatoid and psoriatic arthritis synovial tissue and association with joint damage.类风湿性关节炎和银屑病关节炎滑膜组织中的p53表达及其与关节损伤的关联。
Ann Rheum Dis. 2005 Feb;64(2):183-7. doi: 10.1136/ard.2004.024430.

引用本文的文献

1
Fufang Duzheng tablet attenuates adjuvant rheumatoid arthritis by inhibiting arthritis inflammation and gut microbiota disturbance in rats.复方杜仲片通过抑制大鼠关节炎炎症和肠道微生物群紊乱来减轻佐剂性类风湿性关节炎。
Heliyon. 2024 Jun 7;10(12):e32705. doi: 10.1016/j.heliyon.2024.e32705. eCollection 2024 Jun 30.
2
Laser Capture Microscopy RNA Sequencing for Topological Mapping of Synovial Pathology During Rheumatoid Arthritis.激光捕获显微 RNA 测序在类风湿关节炎中滑膜病变拓扑图谱绘制中的应用。
Arthritis Rheumatol. 2024 Aug;76(8):1243-1251. doi: 10.1002/art.42853. Epub 2024 May 21.
3
Identification of key somatic oncogenic mutation based on a confounder-free causal inference model.
基于无混杂因素因果推理模型的关键体细胞致癌突变鉴定。
PLoS Comput Biol. 2022 Sep 22;18(9):e1010529. doi: 10.1371/journal.pcbi.1010529. eCollection 2022 Sep.
4
Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment.纳米酶工程化中性粒细胞衍生的外泌体通过调节炎症环境减轻晚期类风湿性关节炎的关节损伤。
Bioact Mater. 2022 Mar 23;18:1-14. doi: 10.1016/j.bioactmat.2022.02.017. eCollection 2022 Dec.
5
Serum Reactive Oxygen Metabolites as a Predictor of Clinical Disease Activity Index, Simplified Disease Activity Index, and Boolean Remissions in Rheumatoid Arthritis Patients Treated With Biologic Agents.血清活性氧代谢产物作为接受生物制剂治疗的类风湿关节炎患者临床疾病活动指数、简化疾病活动指数和布尔缓解的预测指标。
Cureus. 2021 Nov 19;13(11):e19759. doi: 10.7759/cureus.19759. eCollection 2021 Nov.
6
Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by Fas ligand via cDNA microarray analysis.通过cDNA微阵列分析对Fas配体调控的类风湿性成纤维样滑膜细胞中的基因进行表达谱分析。
Exp Ther Med. 2021 Sep;22(3):1000. doi: 10.3892/etm.2021.10432. Epub 2021 Jul 15.
7
The p53 status in rheumatoid arthritis with focus on fibroblast-like synoviocytes.类风湿关节炎中的p53状态：聚焦于成纤维细胞样滑膜细胞
Immunol Res. 2021 Jun;69(3):225-238. doi: 10.1007/s12026-021-09202-7. Epub 2021 May 13.
8
Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints.通过对不同数量肿胀关节的类风湿关节炎患者滑膜活检中 DNA 甲基化和基因表达的一致性变化进行特征分析，为类风湿关节炎提供了新的见解。
Front Immunol. 2021 Apr 22;12:651475. doi: 10.3389/fimmu.2021.651475. eCollection 2021.
9
Rational Design and Biological Application of Antioxidant Nanozymes.抗氧化纳米酶的合理设计与生物学应用
Front Chem. 2021 Feb 11;8:831. doi: 10.3389/fchem.2020.00831. eCollection 2020.
10
Enhanced Antioxidant and Cytotoxic Potentials of Lipopolysaccharides-Injected Larvae.注射脂多糖幼虫的抗氧化和细胞毒性增强潜力
Pharmaceutics. 2020 Nov 19;12(11):1111. doi: 10.3390/pharmaceutics12111111.