青少年慢性关节炎和类风湿性关节炎中的p53状态
The p53 status in juvenile chronic arthritis and rheumatoid arthritis.
作者信息
Taubert H, Thamm B, Meye A, Bartel F, Rost A K, Heidenreich D, John V, Brandt J, Bache M, Würl P, Schmidt H, Riemann D
机构信息
Institute of Pathology, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany.
出版信息
Clin Exp Immunol. 2000 Nov;122(2):264-9. doi: 10.1046/j.1365-2249.2000.01358.x.
The aim of this study was to investigate the p53 status in two autoimmune diseases; juvenile chronic arthritis (JCA) and rheumatoid arthritis (RA). In a PCR-sequencing analysis of exons 4-9 of the p53 gene, no mutation was identified, except for the case of an RA synovectomy sample with two mutations of intron 7. p53 gene polymorphisms for codons 36, 47, and 213 were not detected. Codon 72 polymorphism showed an indication of an increased occurrence of the Pro/Pro allelotype in JCA. Expression of P53 protein was comparable for JCA and RA synovectomy samples. For all RA samples P53 protein was detectable, whereas one sample of a JCA patient failed to express P53 protein.
本研究旨在调查两种自身免疫性疾病——青少年慢性关节炎（JCA）和类风湿关节炎（RA）中的p53状态。在对p53基因第4至9外显子进行的聚合酶链反应测序分析中，未发现突变，但有一例RA滑膜切除术样本的内含子7存在两处突变。未检测到密码子36、47和213的p53基因多态性。密码子72多态性显示JCA中Pro/Pro等位基因型的出现频率有所增加。JCA和RA滑膜切除术样本中P53蛋白的表达相当。所有RA样本均可检测到P53蛋白，而一名JCA患者的样本未能表达P53蛋白。
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