Bennett A, Guyatt H
Wellcome Trust Centre for the Epidemiology of Infectious Disease (WTCEID), University of Oxford, South Parks Road, Oxford, UK OX1 3FY.
Parasitol Today. 2000 Feb;16(2):71-4. doi: 10.1016/s0169-4758(99)01544-6.
The widespread use of mebendazole and albendazole for treating intestinal nematode infections in human populations is raising concerns that careful monitoring pro- cedures should be in place to identify any emergence of drug resistance. In this article, Andy Bennett and Helen Guyatt discuss whether benchmark parasitological drug efficacy rates can be defined for these anthelmintics, by analysing published data on cure rates and egg reduction rates in the treatment of Ascaris lumbricoides, Trichuris trichiura and hookworm.
甲苯咪唑和阿苯达唑在人群中广泛用于治疗肠道线虫感染，这引发了人们的担忧，即应该制定仔细的监测程序，以确定是否出现耐药性。在本文中，安迪·贝内特和海伦·盖亚特通过分析已发表的关于治疗蛔虫、鞭虫和钩虫的治愈率和虫卵减少率的数据，讨论了是否可以为这些驱虫药确定基准寄生虫学药物疗效率。
