Bartoloni A, Guglielmetti P, Cancrini G, Gamboa H, Roselli M, Nicoletti A, Paradisi F
Cattedra di Malattie Infettive, Università di Firenze, Italy.
Trop Geogr Med. 1993;45(3):114-6.
The relative efficacy of a single 400 mg dose of albendazole or mebendazole in the treatment of nematode infections was assessed in 2- to 9-year-old children living in two different Bolivian rural communities. Both agents were equally very effective (100% cure rate) in treating ascariasis. Albendazole was clearly more active than mebendazole against hookworm infections, both in terms of egg reduction rate (92.8% vs. 62.4%) and cure rate (81.8% vs. 17.2%). As far as trichuriasis is concerned, albendazole produced a higher egg reduction rate than mebendazole (45.7% vs 15%), but a lower cure rate (33.3% vs 60%). Both drugs were well tolerated.
在居住于玻利维亚两个不同农村社区的2至9岁儿童中，评估了单剂量400毫克阿苯达唑或甲苯达唑治疗线虫感染的相对疗效。两种药物在治疗蛔虫病方面同样非常有效（治愈率100%）。就钩虫感染而言，无论是虫卵减少率（92.8%对62.4%）还是治愈率（81.8%对17.2%），阿苯达唑都明显比甲苯达唑更有效。就鞭虫病而言，阿苯达唑的虫卵减少率高于甲苯达唑（45.7%对15%），但治愈率较低（33.3%对60%）。两种药物耐受性良好。
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