Hu X, Lazar M A
Division of Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Genetics, Penn Diabetes Center, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.
Trends Endocrinol Metab. 2000 Jan-Feb;11(1):6-10. doi: 10.1016/s1043-2760(99)00215-5.
Repression by nuclear receptors plays important roles in acute promyelocytic leukemia and other diseases. Nuclear receptor corepressor (N-CoR) and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) are corepressor proteins whose modular structure facilitates receptor interaction as well as transduction of repression signals involving histone deacetylation, alterations in chromatin structure and direct interactions with the basal transcription machinery. Interactions between nuclear receptors and corepressor complexes have multiple determinants. This allows regulation, and potentially therapeutic manipulation, of receptor, corepressor, cell-type and target-gene specificity.
核受体介导的基因沉默在急性早幼粒细胞白血病及其他疾病中发挥着重要作用。核受体共抑制因子（N-CoR）和视黄酸及甲状腺激素受体沉默介质（SMRT）是共抑制蛋白，其模块化结构有助于受体相互作用以及涉及组蛋白去乙酰化、染色质结构改变和与基础转录机制直接相互作用的抑制信号转导。核受体与共抑制复合物之间的相互作用有多种决定因素。这使得能够对受体、共抑制因子、细胞类型和靶基因特异性进行调控，并可能进行治疗性操控。
