Petrovic Djordjevic Ivana, Petrovic Jelena, Radomirovic Marija, Petrovic Sonja, Biorac Bojana, Jemuovic Zvezdana, Tesic Milorad, Trifunovic Zamaklar Danijela, Nedeljkovic Ivana, Nedeljkovic Beleslin Biljana, Simic Dragan, Zarkovic Milos, Vujisic-Tesic Bosiljka
Clinic for Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Clinic for Digestive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
J Clin Med. 2024 Dec 2;13(23):7348. doi: 10.3390/jcm13237348.
The thyroid gland has an important influence on the heart. Long-term exposure to high levels of thyroid hormones may lead to cardiac hypertrophy and dysfunction. The aim of the study was to evaluate the morphological and functional changes in the left ventricle in patients with hyperthyroidism caused by Graves' disease (GD) in comparison with healthy individuals, as well as to investigate potential differences in these parameters in GD patients in relation to the presence of orbitopathy. The prospective study included 39 patients with clinical manifestations and laboratory confirmation of GD and 35 healthy controls. All participants underwent a detailed echocardiographic examination. The groups were compared according to demographic characteristics (age and gender), heart rate and echocardiographic characteristics. The patients with hyperthyroidism caused by GD had significantly higher values of left ventricular diameter, left ventricular volume and left ventricular mass compared to the healthy controls. In addition, hyperthyroidism significantly influenced the left ventricular contractility and led to the deterioration of the systolic and diastolic function, as shown together by longitudinal strain, color Doppler and tissue Doppler imaging. However, the patients with GD and orbitopathy showed better left ventricular function than those without orbitopathy. Besides the confirmation of previously known findings, our study indicates possible differences in echocardiographic parameters in GD patients in relation to the presence of orbitopathy. Further investigation with larger samples and meta-analyses of data focused on the evaluation of echocardiographic findings in the context of detailed biochemical and molecular analyses is required to confirm our preliminary results and their clinical significance.
甲状腺对心脏有重要影响。长期暴露于高水平甲状腺激素可能导致心脏肥大和功能障碍。本研究的目的是评估格雷夫斯病（GD）所致甲状腺功能亢进患者左心室的形态和功能变化，并与健康个体进行比较，同时调查GD患者这些参数与眼眶病存在与否的潜在差异。这项前瞻性研究纳入了39例有GD临床表现和实验室确诊的患者以及35名健康对照者。所有参与者均接受了详细的超声心动图检查。根据人口统计学特征（年龄和性别）、心率和超声心动图特征对两组进行比较。与健康对照者相比，GD所致甲状腺功能亢进患者的左心室直径、左心室容积和左心室质量值显著更高。此外，甲状腺功能亢进显著影响左心室收缩性，导致收缩和舒张功能恶化，纵向应变、彩色多普勒和组织多普勒成像共同显示了这一点。然而，有眼眶病的GD患者左心室功能比无眼眶病的患者更好。除了证实先前已知的发现外，我们的研究表明，GD患者的超声心动图参数可能因眼眶病的存在而存在差异。需要进行更大样本的进一步研究以及聚焦于在详细生化和分子分析背景下评估超声心动图结果的数据荟萃分析，以证实我们的初步结果及其临床意义。
