Research Division, Hospital Juárez de México, Mexico City, Mexico.
Genetic Laboratory, Hospital Nacional Homeopático, Mexico City, Mexico.
Cancer Control. 2024 Jan-Dec;31:10732748241279514. doi: 10.1177/10732748241279514.
Persistent infection with high-risk human papillomavirus remains the primary factor associated with the progression of cervical squamous intraepithelial lesions and the development of cervical cancer. Nevertheless, a combination of factors, including genetic predisposition, immune response, hormonal influences, and nutritional status, contribute synergistically to the development of cervical cancer. Among the various factors involved in the pathogenesis and therapy of cervical cancer, retinoids have gained considerable attention due to their multifaceted roles in different cellular processes. This review investigates defects within the vitamin A metabolism pathway and their correlation with cervical cancer. Additionally, it integrates epidemiological and experimental findings to discuss the potential utility of retinoid-based therapies, either alone or combined with other therapies, as agents against premalignant lesions and cervical cancer.
高危型人乳头瘤病毒持续感染仍然是与宫颈鳞状上皮内病变进展和宫颈癌发生相关的主要因素。然而，多种因素的共同作用，包括遗传易感性、免疫反应、激素影响和营养状况，协同促进了宫颈癌的发展。在宫颈癌的发病机制和治疗中涉及的各种因素中，类视黄醇因其在不同细胞过程中的多方面作用而受到广泛关注。本综述研究了维生素 A 代谢途径中的缺陷及其与宫颈癌的相关性。此外，还综合了流行病学和实验研究结果，讨论了类视黄醇为基础的治疗方法的潜在应用价值，无论是单独使用还是与其他治疗方法联合使用，作为对抗癌前病变和宫颈癌的药物。
