Barbezange C, Benkö M, Dán A, Harrach B
Veterinary Medical Research Institute, Hungarian Academy of Sciences, P.O. Box 18, H-1581, Budapest, Hungary.
Virus Res. 2000 Jan;66(1):79-85. doi: 10.1016/s0168-1702(99)00123-9.
Until now, the only published ovine adenovirus DNA sequence was the complete genome of ovine adenovirus isolate 287 (OAV287) which, compared to other mammalian adenoviruses, possesses strikingly unique genomic organisation and should properly be classified into a new adenovirus genus. The protease gene sequence of ovine adenovirus type 3 (OAdV-3) was determined and analysed. The results of phylogenetic analysis of the 205 residue long protein demonstrated that OAdV-3 belongs to the genus Mastadenovirus, and is surprisingly closely related to bovine adenovirus type 2. In spite of the common host origin, the evolutionary distance between OAdV-3 and OAV287 proved to be great suggesting that sheep, similarly to cattle and fowl, might be infected by distantly related adenoviruses belonging to different genera.
到目前为止，唯一已发表的绵羊腺病毒DNA序列是绵羊腺病毒分离株287（OAV287）的完整基因组，与其他哺乳动物腺病毒相比，它具有极其独特的基因组结构，理应被归类为一个新的腺病毒属。测定并分析了绵羊3型腺病毒（OAdV-3）的蛋白酶基因序列。对该205个氨基酸长的蛋白质进行系统发育分析的结果表明，OAdV-3属于 Mastadenovirus 属，并且令人惊讶地与牛2型腺病毒密切相关。尽管宿主来源相同，但事实证明，OAdV-3与OAV287之间的进化距离很大，这表明绵羊可能与牛和禽类一样，会感染属于不同属的远缘腺病毒。
