Pauly Maude, Akoua-Koffi Chantal, Buchwald Nanina, Schubert Grit, Weiss Sabrina, Couacy-Hymann Emmanuel, Anoh Augustin Etile, Mossoun Arsène, Calvignac-Spencer Sébastien, Leendertz Siv Aina, Leendertz Fabian H, Ehlers Bernhard
Project Group "Epidemiology of highly pathogenic microorganisms", Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany.
Division 12 "Measles, Mumps, Rubella and Viruses affecting immunocompromised patients", Robert Koch Institute, Seestr. 10, 13353, Berlin, Germany.
Ecohealth. 2015 Sep;12(3):441-52. doi: 10.1007/s10393-015-1032-5. Epub 2015 May 20.
The Taï region in Western Côte d'Ivoire is characterized by extensive overlap of human and animal habitats. This could influence patterns of adenovirus transmission between humans and domestic animals. Fecal samples from humans and various domestic animals were tested for the presence of adenoviruses by PCR. Phylogenetic and species delineation analyses were performed to further characterize the adenoviruses circulating in the region and to identify potential cross-species transmission events. Among domestic animals, adenovirus shedding was frequent (21.6% of domestic mammals and 41.5% of chickens) and the detected strains were highly diverse, several of them representing novel types. Although no evidence for zoonotic transmission of animal adenovirus was obtained, the present study provides concordant evidence in favor of common cross-species transmission of adenoviruses between different animal species and first indications for adenovirus transmission from humans to animals. These findings underline the thus far underestimated importance of reverse zoonotic transmission of viruses and of the role of domestic animals as pathogen reservoirs, "bridge species," or intermediate hosts.
科特迪瓦西部的塔伊地区的特点是人类和动物栖息地广泛重叠。这可能会影响腺病毒在人类和家畜之间的传播模式。通过聚合酶链反应（PCR）检测了人类和各种家畜粪便样本中腺病毒的存在情况。进行了系统发育和物种划分分析，以进一步表征该地区传播的腺病毒，并识别潜在的跨物种传播事件。在家畜中，腺病毒排毒很常见（21.6%的家养哺乳动物和41.5%的鸡），检测到的毒株高度多样，其中几种代表新型。虽然没有获得动物腺病毒人畜共患传播的证据，但本研究提供了一致的证据，支持腺病毒在不同动物物种之间常见的跨物种传播，以及腺病毒从人类传播到家畜的初步迹象。这些发现强调了迄今为止被低估的病毒反向人畜共患传播的重要性，以及家畜作为病原体储存库、“桥梁物种”或中间宿主的作用。
