Graeber M B, Mehraein P
Department of Neuromorphology, Max-Planck-Institute of Neurobiology, Martinsried, Germany.
Eur Arch Psychiatry Clin Neurosci. 1999;249 Suppl 3:10-3. doi: 10.1007/pl00014167.
When a disease becomes as important as Alzheimer's dementia, there is a natural interest in its medical history and in the origin of the underlying disease concept. Key to understanding Alois Alzheimer's views on the disease, which was named after him, are the histological sections of the cases he saw. This histological material was rediscovered in Munich in 1992 and 1997 (Neurogenetics 1997, 1:73-80; 1998, 1:223-228). An extensive neuropathological and molecular genetic analysis of the tissue is currently being carried out. The present article summarizes the history of the rediscovery and provides an analysis of the neuropathology of Alois Alzheimer's first case, Auguste D.
当一种疾病像阿尔茨海默病性痴呆一样重要时，人们自然会对其病史以及潜在疾病概念的起源感兴趣。理解以阿洛伊斯·阿尔茨海默命名的这种疾病的关键在于他所诊治病例的组织学切片。这些组织学材料于1992年和1997年在慕尼黑被重新发现（《神经遗传学》1997年，第1卷：73 - 80页；1998年，第1卷：223 - 228页）。目前正在对该组织进行广泛的神经病理学和分子遗传学分析。本文总结了重新发现的历史，并对阿洛伊斯·阿尔茨海默的首例病例奥古斯特·D的神经病理学进行了分析。
