Longstreth W T, Arnold A M, Manolio T A, Burke G L, Bryan N, Jungreis C A, O'Leary D, Enright P L, Fried L
Department of Neurology, University of Washington, Seattle, USA.
Neuroepidemiology. 2000 Jan-Feb;19(1):30-42. doi: 10.1159/000026235.
To identify potential risk factors for and clinical manifestations of ventricular and sulcal enlargement on cranial magnetic resonance imaging (MRI), 3,301 community-dwelling people 65 years or older without a history of stroke or transient ischemic attack underwent extensive standardized evaluations and MRI. In the multivariate model, increased age and white matter grade on MRI were the dominant risk factors for ventricular and sulcal grade. For ventricular grade, other than race, for which non-Blacks had higher grades, models for men and women shared no other factors. For sulcal grades, models for men and women shared variables reflecting cigarette smoking and diabetes. Clinical features were correlated more strongly with ventricular than sulcal grade and more strongly for women than men. Significant age-adjusted correlations between ventricular grade and the Digit-Symbol Substitution Test were found for men and women. Prospective studies will be needed to extend findings of this cross-sectional analysis.
为了确定头颅磁共振成像（MRI）上脑室和脑沟扩大的潜在风险因素及临床表现，3301名65岁及以上无中风或短暂性脑缺血发作病史的社区居民接受了广泛的标准化评估和MRI检查。在多变量模型中，年龄增长和MRI上的白质分级是脑室和脑沟分级的主要风险因素。对于脑室分级，除了非黑人的脑室分级较高的种族因素外，男性和女性的模型没有其他共同因素。对于脑沟分级，男性和女性的模型有反映吸烟和糖尿病的共同变量。临床特征与脑室分级的相关性比与脑沟分级的相关性更强，女性的相关性比男性更强。在男性和女性中均发现脑室分级与数字符号替换测验之间存在显著的年龄校正相关性。需要进行前瞻性研究以扩展这一横断面分析的结果。
