Luesch H, Yoshida W Y, Moore R E, Paul V J
Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822, USA.
J Nat Prod. 1999 Dec;62(12):1702-6. doi: 10.1021/np990310z.
Lyngbyastatin 2 (1) and norlyngbyastatin 2 (2), new cytotoxic analogues of dolastatin G (3) and nordolastatin G (4), respectively, have been isolated as constituents from a Guamanian variety of the marine cyanobacterium Lyngbya majuscula. Structure elucidation of these cyclic depsipeptides relied on extensive application of 2D NMR techniques. The finding of these new metabolites further supports the proposal that many compounds originally isolated from the sea hare Dolabella auricularia are most likely of cyanobacterial origin.
林格比他汀2（1）和去甲林格比他汀2（2）分别是多拉他汀G（3）和去甲多拉他汀G（4）的新型细胞毒性类似物，已从关岛的一种海洋蓝藻巨大鞘丝藻中分离得到。这些环缩肽的结构解析依赖于二维核磁共振技术的广泛应用。这些新代谢产物的发现进一步支持了以下观点：许多最初从海兔耳状珊瑚中分离出的化合物很可能起源于蓝藻。
