Sitachitta N, Williamson R T, Gerwick W H
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
J Nat Prod. 2000 Feb;63(2):197-200. doi: 10.1021/np990466z.
Yanucamides A (1) and B (2) were isolated from the lipid extract of a Lyngbya majuscula and Schizothrixsp. assemblage collected at Yanuca Island, Fiji. The structures of compounds 1 and 2 were determined by spectroscopic methods. Both compounds contain a unique 2,2-dimethyl-3-hydroxy-7-octynoic acid, which has previously been described only as a component of kulolide-1 (3) and kulokainalide-1 (4), metabolites from the marine mollusk Philinopsis speciosa. Thus, the isolation of the yanucamides from this cyanobacterial assemblage supports the hypothesis that the kulolides and related metabolites are of cyanobacterial origin.
从斐济亚努卡岛采集的一种巨大鞘丝藻（Lyngbya majuscula）和裂须藻属（Schizothrixsp.）组合的脂质提取物中分离出了亚努卡酰胺A（1）和B（2）。通过光谱方法确定了化合物1和2的结构。这两种化合物都含有一种独特的2,2 - 二甲基 - 3 - 羟基 - 7 - 辛炔酸，此前仅被描述为海洋软体动物美丽拟海牛（Philinopsis speciosa）的代谢产物库洛利德 - 1（3）和库洛卡因内酯 - 1（4）的组成部分。因此，从这种蓝藻组合中分离出亚努卡酰胺支持了库洛利德及相关代谢产物起源于蓝藻的假说。
