Williams Philip G, Moore Richard E, Paul Valerie J
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
J Nat Prod. 2003 Oct;66(10):1356-63. doi: 10.1021/np0302145.
The structure of lyngbyastatin 3 (1), including the configurations of the two unusual amino acid residues, viz., the 3-amino-2-methylhexanoic acid (Amha) and 4-amino-2,2-dimethyl-3-oxopentanoic acid units (Ibu), has been established by chemical degradation. Analysis of the cyanobacterial samples of lyngbyastatin 3 (1), lyngbyastatin 1 (2), and dolastatin 12 (3) demonstrated that they are mixtures of Ibu epimers [R (major) and S (minor)], whereas the structurally related majusculamide C (4) is a single diastereomer having an S-Ibu unit.
通过化学降解确定了灵菌红素 3（1）的结构，包括两个不寻常氨基酸残基的构型，即 3-氨基-2-甲基己酸（Amha）和 4-氨基-2,2-二甲基-3-氧代戊酸单元（Ibu）。对灵菌红素 3（1）、灵菌红素 1（2）和多拉司他汀 12（3）的蓝藻样品分析表明，它们是 Ibu 差向异构体[R（主要）和 S（次要）]的混合物，而结构相关的大孢酰胺 C（4）是具有 S-Ibu 单元的单一非对映异构体。
