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低分子量肝素用于人工心脏瓣膜：治疗失败

Low-molecular-weight heparin for prosthetic heart valves: treatment failure.

作者信息

Lev-Ran O, Kramer A, Gurevitch J, Shapira I, Mohr R

机构信息

Department of Thoracic and Cardiovascular Surgery, Tel-Aviv Sourasky Medical Center, Israel.

出版信息

Ann Thorac Surg. 2000 Jan;69(1):264-5; discussion 265-6. doi: 10.1016/s0003-4975(99)00874-7.

DOI:10.1016/s0003-4975(99)00874-7
PMID:10654529
Abstract

There is no adequate substitute therapy for patients with prosthetic heart valves, in whom anticoagulation with warfarin or unfractionated heparin must be withheld. In the literature there are several reports describing successful treatment with low-molecular-weight heparin in patients with prosthetic heart valves. We report two cases of low-molecular-weight heparin treatment failure resulting in thrombosed prosthetic heart valves with stormy clinical presentations, who underwent successful valve replacements.

摘要

对于人工心脏瓣膜患者，没有足够的替代疗法，这类患者必须停用华法林或普通肝素进行抗凝治疗。文献中有几篇报道描述了低分子量肝素成功治疗人工心脏瓣膜患者的情况。我们报告了两例低分子量肝素治疗失败导致人工心脏瓣膜血栓形成且临床表现严重的病例，这两名患者均成功接受了瓣膜置换术。

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Low-molecular-weight heparin for prosthetic heart valves: treatment failure.低分子量肝素用于人工心脏瓣膜：治疗失败
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