Dritschilo A, Cassady J R, Camitta B, Jaffe N, Furman L, Traggis D
Cancer. 1976 Jun;37(6):2729-35. doi: 10.1002/1097-0142(197606)37:6<2729::aid-cncr2820370624>3.0.co;2-m.
The results of central nervous system (CNS) treatment with craniocervical irradiation and intrathecal methotrexate in 117 children with ALL achieved at the Joint Center for Radiation Therapy. The Children's Hospital Medical Center, and The Sidney Farber Cancer Center are presented. A classification related to meningeal disease which correlated with prognosis is presented and the patients are analyzed within these groups. Of 80 patients classified in the most favorable groups (I and II), no child has suffered primary CNS relapse. Of the remaining 37 patients in less favorable groups (III, IV, and V), eight patients have experienced CNS relapse, five following or in conjunction with bone marrow relapse. The technical features of irradiation are reviewed and related to success of the treatment.
本文介绍了在联合放射治疗中心、儿童医院医学中心和西德尼·法伯癌症中心，对117例急性淋巴细胞白血病（ALL）患儿采用颅颈照射和鞘内注射甲氨蝶呤进行中枢神经系统（CNS）治疗的结果。文中提出了一种与脑膜疾病相关且与预后相关的分类方法，并在这些组内对患者进行了分析。在分类为最有利组（I和II）的80例患者中，没有儿童发生原发性CNS复发。在其余37例不太有利组（III、IV和V）的患者中，有8例发生了CNS复发，其中5例在骨髓复发之后或与骨髓复发同时发生。文中回顾了照射的技术特点及其与治疗成功的关系。
