Balian A, Fromont C, Naveau S, Bonte E, Belloula D, Giraud V, Montembault S, Capron F, Chaput J C
Department of Hepatology, Antoine Béclère Hospital, Clamart, France.
Eur J Gastroenterol Hepatol. 1999 Dec;11(12):1417-9. doi: 10.1097/00042737-199912000-00013.
Duodeno-pancreatic biochemically polyfunctional endocrine tumour is a well known entity. Usually, only one hormone is responsible for the clinical features. We report a case of aggressive combined glucagonoma and gastrinoma tumour without metastases, causing respectively diabetic ketoacidosis and fulminant peptic ulcer, and death. Occasional patients can present with clinical features of both glucagonoma and gastrinoma. Diabetic patients exhibiting migratory skin lesions should be suspected of glucagonoma. In addition, a multidisciplinary approach to such patients including dermatologists, surgeons, radiologists and endoscopists is mandatory.
十二指肠 - 胰腺生化多官能内分泌肿瘤是一种众所周知的实体。通常，只有一种激素导致临床症状。我们报告一例侵袭性联合胰高血糖素瘤和胃泌素瘤病例，无转移，分别导致糖尿病酮症酸中毒和暴发性消化性溃疡，并最终死亡。少数患者可同时出现胰高血糖素瘤和胃泌素瘤的临床症状。出现游走性皮肤病变的糖尿病患者应怀疑患有胰高血糖素瘤。此外，对于此类患者，包括皮肤科医生、外科医生、放射科医生和内镜医生在内的多学科治疗方法是必不可少的。
