Jakoby M G, Semenkovich C F
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Curr Opin Nephrol Hypertens. 2000 Jan;9(1):11-5. doi: 10.1097/00041552-200001000-00003.
Calcification is a component of vascular disease that usually occurs in concert with atheroma formation but through distinct pathophysiological processes. Vessel wall osteoprogenitor cells known as calcifying vascular cells can form bone matrix proteins and calcified nodules, analogous to osteoblastic differentiation in bone. These cells have been isolated from the tunica media of bovine and human arteries, and both in-vitro tissue culture models and mouse models of vascular calcification have been established. Studies of the effects of diabetes mellitus, hyperlipidemia, estrogens and glucocorticoids on calcifying vascular cell function provide insight into the relationship between common human disease states and vascular calcification.
钙化是血管疾病的一个组成部分，通常与动脉粥样硬化形成同时发生，但通过不同的病理生理过程。被称为钙化血管细胞的血管壁骨祖细胞可以形成骨基质蛋白和钙化结节，类似于骨中的成骨细胞分化。这些细胞已从牛和人的动脉中膜分离出来，并且已经建立了血管钙化的体外组织培养模型和小鼠模型。对糖尿病、高脂血症、雌激素和糖皮质激素对钙化血管细胞功能影响的研究，为了解常见人类疾病状态与血管钙化之间的关系提供了线索。
