• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation?

作者信息

Glabe C

出版信息

Nat Med. 2000 Feb;6(2):133-4. doi: 10.1038/72215.

DOI:10.1038/72215
PMID:10655093
Abstract
摘要

相似文献

1
Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation?阿尔茨海默病是否会影响淀粉样蛋白降解与积累之间的平衡？
Nat Med. 2000 Feb;6(2):133-4. doi: 10.1038/72215.
2
sorLA: sorting out APP.sorLA：分拣淀粉样前体蛋白（APP）
Mol Interv. 2006 Apr;6(2):74-6, 58. doi: 10.1124/mi.6.2.4.
3
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.第二种源自淀粉样β蛋白前体的细胞毒性蛋白水解肽。
Nat Med. 2000 Apr;6(4):397-404. doi: 10.1038/74656.
4
Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models.胱抑素C抑制阿尔茨海默病小鼠模型中的β-淀粉样蛋白沉积。
Nat Genet. 2007 Dec;39(12):1440-2. doi: 10.1038/ng.2007.29. Epub 2007 Nov 18.
5
Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease.阿尔茨海默病APPswe/PS1dE9小鼠模型中淀粉样蛋白沉积的特征分析
Neurobiol Dis. 2006 Dec;24(3):516-24. doi: 10.1016/j.nbd.2006.08.017. Epub 2006 Oct 5.
6
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.缺乏β-分泌酶1（阿尔茨海默病β-分泌酶）的小鼠具有正常表型且β-淀粉样蛋白生成被消除。
Nat Neurosci. 2001 Mar;4(3):231-2. doi: 10.1038/85059.
7
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.β-分泌酶1（BACE1）是神经元生成β淀粉样肽（Aβ肽）的主要β-分泌酶。
Nat Neurosci. 2001 Mar;4(3):233-4. doi: 10.1038/85064.
8
Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit.神经元中性内肽酶过表达与β-淀粉样蛋白相关的空间记忆缺陷的减轻有关。
Neurobiol Dis. 2006 Dec;24(3):475-83. doi: 10.1016/j.nbd.2006.08.003. Epub 2006 Sep 27.
9
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.生长抑素通过调节蛋白水解降解来调控脑淀粉样β肽Aβ42。
Nat Med. 2005 Apr;11(4):434-9. doi: 10.1038/nm1206. Epub 2005 Mar 20.
10
Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, regulation of proteolysis, and implications for drug development.阿尔茨海默病β-淀粉样蛋白前体的细胞质结构域：功能、蛋白水解调节及其对药物开发的意义。
J Neurosci Res. 2005 Apr 15;80(2):151-9. doi: 10.1002/jnr.20408.

引用本文的文献

1
Intranasal Delivery of Collagen-Loaded Neprilysin Clears Beta-Amyloid Plaques in a Transgenic Alzheimer Mouse Model.载有胶原的中性内肽酶经鼻给药可清除转基因阿尔茨海默病小鼠模型中的β-淀粉样蛋白斑块。
Front Aging Neurosci. 2021 Apr 22;13:649646. doi: 10.3389/fnagi.2021.649646. eCollection 2021.
2
Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques.以成年阿尔茨海默病小鼠（过表达带有瑞典-荷兰-爱荷华突变的淀粉样前体蛋白）的全脑器官型振动切片作为研究β-淀粉样蛋白斑块清除的模型。
Front Aging Neurosci. 2015 Apr 9;7:47. doi: 10.3389/fnagi.2015.00047. eCollection 2015.
3
Intracellular cleavage of amyloid β by a viral protease NIa prevents amyloid β-mediated cytotoxicity.
病毒蛋白酶NIa对淀粉样β蛋白的细胞内切割可防止淀粉样β蛋白介导的细胞毒性。
PLoS One. 2014 Jun 10;9(6):e98650. doi: 10.1371/journal.pone.0098650. eCollection 2014.
4
Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease.含姜黄素和胆固醇的双价配体作为阿尔茨海默病中Aβ斑块的荧光探针
ACS Chem Neurosci. 2012 Feb 15;3(2):141-146. doi: 10.1021/cn200122j. Epub 2011 Dec 11.
5
Altered NEP2 expression and activity in mild cognitive impairment and Alzheimer's disease.轻度认知障碍和阿尔茨海默病中 NEP2 表达和活性的改变。
J Alzheimers Dis. 2012;28(2):433-41. doi: 10.3233/JAD-2011-111307.
6
ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue.抗中性粒细胞胞浆抗体：一类可结合并染色人体组织中淀粉样斑块的荧光探针。
ACS Chem Neurosci. 2011 May 18;2(5):249-255. doi: 10.1021/cn200018v.
7
Estrogen regulation of the neprilysin gene through a hormone-responsive element.雌激素通过激素反应元件调节脑啡肽酶基因。
J Mol Neurosci. 2009 Sep;39(1-2):22-6. doi: 10.1007/s12031-008-9168-1. Epub 2009 Jan 6.
8
Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis.应对晚发性阿尔茨海默病的复杂性：应用两阶段分析方法处理异质性和上位性
Genet Epidemiol. 2008 Apr;32(3):187-203. doi: 10.1002/gepi.20294.
9
Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain.唐氏综合征和正常大脑中α-和β-分泌酶活性与年龄及β-淀粉样蛋白的关系
Neurobiol Aging. 2007 Oct;28(10):1493-506. doi: 10.1016/j.neurobiolaging.2006.06.023. Epub 2006 Aug 9.
10
Aging-related correlation of insulin-degrading enzyme with gamma-secretase-generated products involving insulin and glucose levels in transgenic mice.
Neurochem Res. 2005 Sep;30(9):1171-7. doi: 10.1007/s11064-005-7952-7.