Yokota S, Miki K
Department of Internal Medicine, Toneyama National Hospital, Osaka, Japan.
Kekkaku. 1999 Dec;74(12):873-7.
The effects of INH (Isoniazid) inhalation on clinical findings were studied retrospectively in 39 patients with endobronchial tuberculosis (EBTB). The diagnosis of EBTB and the assessment of bronchial stenosis were based on bronchoscopic examination. We divided the patients in two groups: 13 patients had been treated with only systemic chemotherapy of lung tuberculosis, and 26 patients had been treated with systemic chemotherapy and INH inhalation (INH 200 mg/day). As a result, there were no significant differences between both groups for duration of sputum culture positive and until ESR normalization. However, a significant improvement in bronchial stenosis and reduction of respiratory symptoms were seen in patients treated with systemic chemotherapy and INH inhalation. In conclusion, INH inhalation in addition to standard chemotherapy of lung tuberculosis is useful to prevent bronchial stenosis for the patients with EBTB.
我们对39例支气管内膜结核（EBTB）患者进行回顾性研究，以探讨异烟肼（INH）吸入治疗对临床症状的影响。EBTB的诊断和支气管狭窄的评估均基于支气管镜检查。我们将患者分为两组：13例仅接受了肺结核全身化疗，26例接受了全身化疗及INH吸入治疗（INH 200mg/天）。结果，两组在痰培养阳性持续时间及血沉恢复正常所需时间方面无显著差异。然而，接受全身化疗及INH吸入治疗的患者支气管狭窄有显著改善，呼吸道症状减轻。总之，对于EBTB患者，在肺结核标准化疗基础上加用INH吸入有助于预防支气管狭窄。
