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用于应对全球健康挑战的工程药物输送装置。

Engineered drug delivery devices to address Global Health challenges.

机构信息

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Harvard Radiation Oncology Program, Boston, MA 02114, USA.

出版信息

J Control Release. 2021 Mar 10;331:503-514. doi: 10.1016/j.jconrel.2021.01.035. Epub 2021 Jan 28.

DOI:10.1016/j.jconrel.2021.01.035
PMID:33516755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7842133/
Abstract

There is a dire need for innovative solutions to address global health needs. Polymeric systems have been shown to provide substantial benefit to all sectors of healthcare, especially for their ability to extend and control drug delivery. Herein, we review polymeric drug delivery devices for vaccines, tuberculosis, and contraception.

摘要

现在迫切需要创新的解决方案来满足全球健康需求。聚合物系统已被证明可以为医疗保健的各个领域提供实质性的好处，尤其是因为它们具有延长和控制药物释放的能力。本文综述了聚合物药物输送装置在疫苗、结核病和避孕方面的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/98019a86701a/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/d6c6078da6bf/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/d093d6d8f2e8/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/5948cd10f5d5/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/7ea0c09620cb/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/98019a86701a/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/d6c6078da6bf/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/d093d6d8f2e8/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/5948cd10f5d5/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/7ea0c09620cb/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f83/7842133/98019a86701a/gr4_lrg.jpg

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Transdermal microneedles for the programmable burst release of multiple vaccine payloads.经皮微针用于可编程突发释放多种疫苗有效负载。
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An mRNA Vaccine against SARS-CoV-2 - Preliminary Report.
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Stiffness-Controlled Hydrogels for 3D Cell Culture Models.用于3D细胞培养模型的刚度控制水凝胶
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