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[结核性气管支气管狭窄的外科治疗及支气管内支架置入术]

[Surgical treatment and endobronchial stentplacement for tuberculous tracheobronchial strictures].

作者信息

Nakajima Y, Shiraishi Y

机构信息

Department of Chest Surgery, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.

出版信息

Kekkaku. 1999 Dec;74(12):897-905.

Abstract

MATERIALS AND RESULTS

We have seventeen cases of operation for the tuberculous tracheobronchial cicatric strictures. Ten of them were tracheobronchial reconstructions to the strictures, and other seven cases were resections of the peripheral destroyed or infected pulmonary tissues (lobectomy 1, pneumonectomy 6). In the reconstructions seven cases were of sleeve lobectomy (left 6, right 1), three were of segmental resection of left main bronchus and trachea. The results were good in 6 sleeve lobectomies and 2 segmental resections of left main bronchus. All these 8 cases had no marked tracheal strictures, and their postoperative troubles were mild. Two cases with tracheal stricture (left sleeve lobectomy and tracheal segmental resection with left pneumonectomy) suffered from postoperative major complications. In the former the tracheal stentplacement was needed for a long time, in the latter its tracheal anastomosis was disrupted and the patient died six months later. Peripheral pulmonary resections could get the good results to disappear their longstanding various symptoms and signs. We tried to do the endoscopic dilatation or stenting to three tracheal strictures. One case was treated by the endoscopic electrocauteries and baloon dilatations totally in 15 times, but its late prognosis was poor and the patient died of the ventilatory disturbance 53 months later. Another one was the case of left upper sleeve lobectomy with tracheal stricture, and already mentioned its tracheal stent. In the third case the tracheal wall was damaged so deeply and extensively that the tracheomalacia might cause to suffocate. Then the tracheal stricture had been dilated with several sized stents step by step, finally a silicon long T-tube was inserted into the trachea successfully. But 10 days later a hard mucous plug impacted inside the tube and the patient died. In recent Japanese literatures and meeting reports, there were sixty cases of endoscopic surgeries and stentplacement for tuberculous tracheobronchial strictures. In these cases about half ones were for the left main bronchus, one third for the trachea. In the former the rupture of bronchial wall happened in 6%, the dislocations of stent in 22% and restrictures came out in 26%. In the latter the complication death occurred in 14%, stent dislocations in 30% and restrictures in 46%, so it was only 30% to become to be free from tracheal stents.

CONCLUSIONS

For the treatment of tuberculous cicatric tracheobronchial strictures, the reconstruction of main bronchus in cases without marked tracheal stenosis is a good indication to regain the lost pulmonary function. The resection of peripheral lung is also a good indication to reduce many symptoms and signs from them. However various endoscopic treatments involving stentplacement has not been established yet enough, especially in a point of late prognosis, so we have to be careful to do such procedures. The new apparatus with more durable and easily handled will be expected to develop in near future.

摘要

材料与结果

我们有17例结核性气管支气管瘢痕狭窄手术病例。其中10例为气管支气管狭窄重建术,另外7例为外周毁损或感染肺组织切除术(肺叶切除术1例,全肺切除术6例)。在重建术中,7例为袖状肺叶切除术(左6例,右1例),3例为左主支气管和气管节段切除术。6例袖状肺叶切除术和2例左主支气管节段切除术效果良好。这8例均无明显气管狭窄,术后并发症轻微。2例气管狭窄患者(左袖状肺叶切除术及左全肺切除气管节段切除术)术后出现严重并发症。前者长期需要放置气管支架,后者气管吻合口破裂,患者6个月后死亡。外周肺切除术能有效消除长期存在的各种症状和体征。我们对3例气管狭窄患者尝试进行内镜扩张或支架置入术。1例患者共接受15次内镜电灼和球囊扩张治疗,但其远期预后较差,患者53个月后死于呼吸衰竭。另一例为左肺上叶袖状肺叶切除术合并气管狭窄,已提及放置气管支架情况。第3例患者气管壁损伤深且广泛,可能导致气管软化窒息。遂逐步用不同尺寸支架扩张气管狭窄,最终成功置入硅质长T形管。但10天后管内形成坚硬黏液栓,患者死亡。在近期日本文献和会议报告中,有60例结核性气管支气管狭窄的内镜手术及支架置入病例。其中约一半为左主支气管病变,三分之一为气管病变。前者支气管壁破裂发生率为6%,支架移位率为22%,再狭窄率为26%。后者并发症死亡率为14%,支架移位率为30%,再狭窄率为46%,仅30%患者无需气管支架。

结论

对于结核性瘢痕气管支气管狭窄的治疗,在无明显气管狭窄的情况下,主支气管重建是恢复肺功能的良好适应证。外周肺切除也是减轻多种症状和体征的良好适应证。然而,包括支架置入在内的各种内镜治疗方法尚未充分确立,尤其是在远期预后方面,因此我们在进行此类操作时必须谨慎。有望在不久的将来研发出更耐用且操作简便的新设备。

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