Orlova T A, Khudov V V, Bobrovnitskiĭ I P
Aviakosm Ekolog Med. 1999;33(6):3-11.
The review demonstrates the importance of diagnosing early forms of atherosclerotic disorders in pilots. A particular attention has been given to hyperlipidemia as the leading risk factor accompanied by accumulation of atherogenic lipoproteins in blood. Underlying mechanisms have been analyzed, normal contents of main lipids in blood in various age groups were outlined. Discussed are various outlooks on the diagnostic significance of hyperlipidemias, and a principally new method of calculating the professional biological age. The relation between blood levels of lipids and other immunobiochemical indices has been traced. All round consideration is given to status of the immune system as well as changes preceding and attendant to atherosclerosis, and the role of lipid peroxidation in atherogenesis. The necessity to correct disorders in lipid metabolism with, specifically, dietary measures, pharmacological correction and non-medicinal therapy has been demonstrated. Application of of corrective measures depending on the severity of atherosclerosis is substantiated.
该综述表明了在飞行员中诊断早期动脉粥样硬化疾病形式的重要性。特别关注了高脂血症这一首要危险因素，以及血液中致动脉粥样硬化脂蛋白的积累。分析了潜在机制，概述了各年龄组血液中主要脂质的正常含量。讨论了对高脂血症诊断意义的各种观点，以及一种全新的计算职业生物学年龄的方法。追踪了血脂水平与其他免疫生化指标之间的关系。全面考虑了免疫系统的状态以及动脉粥样硬化之前和伴随的变化，以及脂质过氧化在动脉粥样硬化形成中的作用。已经证明有必要通过饮食措施、药物纠正和非药物治疗来纠正脂质代谢紊乱。根据动脉粥样硬化的严重程度应用纠正措施是有依据的。
