Thomas H P, Steinhagen-Thiessen E
Charité, Medizinische Fakultät der Humboldt-Universität, Berlin.
MMW Fortschr Med. 1999 Sep 16;141(37):34-6.
In cross-sectional investigations, disturbances in lipid metabolism are found in about 40-50% of the population. A particularly close correlation is found between cardiovascular mortality and elevated LDL cholesterol. But disordered triglyceride metabolism and increased concentrations of lipoprotein(a) are also considered major factors that further the atherosclerosis process. A knowledge of the underlying mechanisms and the possibilities for influencing lipid metabolic disorders provide the basis for rational treatment. Unfortunately, disorders in lipid metabolism often continue to go undetected until the so-called endpoints (infarction, stroke) have occurred.
在横断面调查中，约40%-50%的人群存在脂质代谢紊乱。心血管死亡率与低密度脂蛋白胆固醇升高之间存在特别密切的相关性。但甘油三酯代谢紊乱和脂蛋白(a)浓度升高也被认为是促进动脉粥样硬化进程的主要因素。了解潜在机制以及影响脂质代谢紊乱的可能性为合理治疗提供了依据。不幸的是，脂质代谢紊乱往往在所谓的终点事件（梗死、中风）发生之前一直未被发现。
