Zhao H X, Stenhouse E, Soper C, Hughes P, Sanderson E, Baumer J H, Demaine A G, Millward B A
Molecular Medicine Research Group, Plymouth Postgraduate Medical School, University of Plymouth, Devon, UK.
Diabet Med. 1999 Dec;16(12):1030-5. doi: 10.1046/j.1464-5491.1999.00175.x.
To determine the incidence of Type 1 diabetes mellitus (DM) in children aged 0-15 years in the far south-west of England between 1975 and 1996.
Patient information was collected to set up the Cornwall and Plymouth Children's Diabetes Register (CPCDR) through two main data sources; hospitals and the general practitioners in all surgeries in the study region. All children under 16 years living within Cornwall and the Isles of Scilly, and the former Plymouth Health Authorities and diagnosed as having Type 1 DM during the study period were included. The case ascertainment was estimated by a capture-recapture method. Trends and differences in incidence of sex, age, time period and district of diagnosis were analysed by Poisson regression analysis. Roger's method was used to estimate the seasonal variations.
A total of 522 subjects aged between 0 and 15 years were identified from 01/01/1975 to 31/12/1996, giving an overall crude incidence of 14.9/ 100 000 population/year. The case ascertainment was 94.4% (95% confidence interval (CI) 91.4- 97.6%) for the whole register. Poisson regression analysis showed that a significant increase of incidence (2.49% per year) was observed throughout the 22-year study period, which was mainly a result of the significant increase in the 0-4 year age-group (6.29% per year). The incidence significantly differed among the 22-years (P = 0.007), the three age groups (0-4, 5-9 and 10-14 years, P<0.001) and different sexes (P=0.049). The significant seasonal variations were detected with peak incidence appearing in autumn and winter.
The first validated childhood-onset diabetes register has been set up in the far south-west of England. The incidence of childhood Type 1 DM in this region has increased significantly over the past two decades, especially in children under 5 years.
确定1975年至1996年间英格兰西南部最远端0至15岁儿童1型糖尿病（DM）的发病率。
通过两个主要数据源收集患者信息，以建立康沃尔和普利茅斯儿童糖尿病登记册（CPCDR）；研究区域内所有外科手术的医院和全科医生。纳入了居住在康沃尔和锡利群岛以及前普利茅斯卫生当局内且在研究期间被诊断为患有1型糖尿病的所有16岁以下儿童。通过捕获-再捕获方法估计病例确诊率。采用泊松回归分析来分析性别、年龄、时间段和诊断地区发病率的趋势及差异。使用罗杰方法估计季节变化。
在1975年1月1日至1996年12月31日期间，共识别出522名年龄在0至15岁之间的受试者，总体粗发病率为每年14.9/10万人口。整个登记册的病例确诊率为94.4%（95%置信区间（CI）91.4 - 97.6%）。泊松回归分析显示，在整个22年的研究期间，发病率显著增加（每年2.49%），这主要是0至4岁年龄组显著增加（每年6.29%）的结果。发病率在22年期间（P = 0.007）、三个年龄组（0至4岁、5至9岁和10至14岁，P<0.001）以及不同性别之间（P = 0.049）存在显著差异。检测到显著的季节变化，发病率高峰出现在秋季和冬季。
在英格兰西南部最远端建立了首个经过验证的儿童期发病糖尿病登记册。该地区儿童1型糖尿病的发病率在过去二十年中显著增加，尤其是5岁以下儿童。
