长期血糖控制对2型糖尿病患者血清脂蛋白(a)水平的影响。

The effect of long-term glycaemic control on serum lipoprotein(a) levels in patients with Type 2 diabetes mellitus.

作者信息

Song K H, Ahn Y B, Yoon K H, Cha B Y, Lee K W, Son H Y, Kang S K

机构信息

Department of Internal Medicine, The Catholic University of Korea, Seoul.

出版信息

Diabet Med. 1999 Dec;16(12):1036-9. doi: 10.1046/j.1464-5491.1999.00183.x.

DOI:10.1046/j.1464-5491.1999.00183.x

PMID:10656233

Abstract

AIMS

To examine whether long-term glycaemic control affects lipoprotein(a) (Lp(a)) levels in patients with Type 2 diabetes mellitus.

METHODS

Eighty-nine Type 2 diabetic patients (38 men, 51 women) were recruited from the diabetes clinic. Based on HbA1c concentrations at baseline, patients were divided into two groups: those with HbA1c < 8.0% (n =45) and those with HbA1c > or = 8.0% (n=44). Comparisons of Lp(a) levels were made between both groups. The effect of long-term glycaemic control on Lp(a) levels was investigated in a subgroup of 20 patients, selected from those with baseline HbA1c > or = 8%. All these patients were treated with a goal of HbA1c <7%.

RESULTS

Lp(a) levels were not significantly different between those with HbA1c< 8.0% and those with HbA1c, > or = 8.0%. No correlation between Lp(a) and HbA1c or fasting blood glucose levels was noted in diabetic patients as a whole. After 2 years of intensive glycaemic control, all patients exhibited remarkable improvement of therapy: their average HbA1c levels were 6.5 +/- 0.7%, being < 7% in 70% of patients. However, no change in Lp(a) levels were observed after 2 years (19.5 +/- 14.8-21.4 +/- 13.4 mg/dl, P = 0.390).

CONCLUSION

These results indicate that improvement of glycaemic control does not affect serum Lp(a) levels in patients with Type 2 diabetes mellitus.

摘要

目的

研究长期血糖控制是否会影响2型糖尿病患者的脂蛋白(a) [Lp(a)]水平。

方法

从糖尿病门诊招募了89例2型糖尿病患者（38例男性，51例女性）。根据基线糖化血红蛋白（HbA1c）浓度，将患者分为两组：HbA1c < 8.0%的患者（n = 45）和HbA1c≥8.0%的患者（n = 44）。比较两组的Lp(a)水平。在基线HbA1c≥8%的患者中选取20例患者组成亚组，研究长期血糖控制对Lp(a)水平的影响。所有这些患者的治疗目标是HbA1c < 7%。

结果

HbA1c < 8.0%的患者与HbA1c≥8.0%的患者之间的Lp(a)水平无显著差异。总体糖尿病患者中，未发现Lp(a)与HbA1c或空腹血糖水平之间存在相关性。经过2年的强化血糖控制后，所有患者的治疗均有显著改善：他们的平均HbA1c水平为6.5±0.7%，70%的患者HbA1c < 7%。然而，2年后Lp(a)水平未观察到变化（19.5±14.8 - 21.4±13.4 mg/dl，P = 0.390）。