帕金森病患者的碘-123 碘苯并呋喃（I-123 IBF）单光子发射计算机断层扫描（SPECT）

Iodine-123 iodobenzofuran (I-123 IBF) SPECT in patients with parkinsonism.

作者信息

Nakabeppu O, Nakajo M, Mitsuda M, Tsuchimochi S, Tani A, Osame M

机构信息

Department of Radiology, Faculty of Medicine, Kagoshima University, Japan.

出版信息

Ann Nucl Med. 1999 Dec;13(6):447-52. doi: 10.1007/BF03164943.

DOI:10.1007/BF03164943

PMID:10656283

Abstract

I-123 IBF is a dopaminergic antagonist which is suitable for SPECT imaging of D2 receptors. The purpose of this study is to evaluate the potential usefulness of semi-quantitative parameters obtained from brain SPECT data of I-123 IBF for differential diagnosis in patients with parkinsonism (PN). Subjects were 10 patients with PN: 2 patients with striato-nigral degeneration (SND), 5 patients with Parkinson's disease (PD), 2 patients with progressive supranuclear palsy (PSP) and one patient with olivo-ponto-cerebellar atrophy (OPCA). The data were acquired with a triple-head gamma camera at 2 hours after intravenous injection of 167 MBq of I-123 IBF. Transverse images were reconstructed by means of filtered backprojection, and attenuation correction was performed by Chang's method (mu = 0.08). The basal ganglia-to-frontal cortex ratio (GFR) and the basal ganglia-to-occipital cortex ratio(GOR) on slices of 5 different thicknesses were calculated. The GFR and GOR were lower in the SND group than in the other disease groups in all slices with different thicknesses (7.2 mm, 14.4 mm, 21.6 mm, 28.8 mm and 43.2 mm). The semiquantitative parameters (GFR and GOR) obtained from brain SPECT data at 2 hours after intravenous injection of I-123 IBF may be useful for differential diagnosis in patients with PN.

摘要

I-123 IBF是一种多巴胺能拮抗剂，适用于D2受体的单光子发射计算机断层扫描（SPECT）成像。本研究的目的是评估从I-123 IBF脑SPECT数据获得的半定量参数在帕金森综合征（PN）患者鉴别诊断中的潜在用途。研究对象为10例PN患者：2例纹状体黑质变性（SND）患者、5例帕金森病（PD）患者、2例进行性核上性麻痹（PSP）患者和1例橄榄桥脑小脑萎缩（OPCA）患者。在静脉注射167 MBq的I-123 IBF后2小时，使用三头伽马相机采集数据。通过滤波反投影重建横向图像，并采用Chang法（μ = 0.08）进行衰减校正。计算5种不同厚度切片上的基底节与额叶皮质比值（GFR）和基底节与枕叶皮质比值（GOR）。在所有不同厚度（7.2 mm、14.4 mm、21.6 mm、28.8 mm和43.2 mm）的切片中，SND组的GFR和GOR均低于其他疾病组。静脉注射I-123 IBF后2小时从脑SPECT数据获得的半定量参数（GFR和GOR）可能有助于PN患者的鉴别诊断。