Pérez de Luque A, Galindo J C, Macías F A, Jorrín J
Departamento de Bioquímica y Biologiá Molecular, ETSIAM, Universidad de Córdoba, Spain.
Phytochemistry. 2000 Jan;53(1):45-50. doi: 10.1016/s0031-9422(99)00485-9.
Six sunflower sesquiterpene lactone models which share structural features of the lactone rings of strigol and its synthetic analogues, the GR family, with different conformational flexibilities were tested as Orobanche cumana germination stimulants. Among them, parthenolide and 3,5-dihydroxydehydrocostus-lactone significantly increased O. cumana germination, presenting higher activity than GR-24, used as a standard in the germination bioassay. The effect of these two compounds is species-specific, showing no germination stimulant activity on other Orobanche spp. tested (O. crenata, O. ramosa and O. aegyptiaca). Data presented are discussed in terms of a structure-activity relationship.
测试了六种向日葵倍半萜内酯模型，它们具有独脚金内酯及其合成类似物（GR家族）内酯环的结构特征，且具有不同的构象灵活性，以此作为埃及列当发芽刺激剂。其中，小白菊内酯和3,5-二羟基脱氢木香内酯显著提高了埃及列当的发芽率，在发芽生物测定中表现出比用作标准的GR-24更高的活性。这两种化合物的作用具有物种特异性，对测试的其他列当属物种（镰形列当、分枝列当和埃及列当）没有发芽刺激活性。根据构效关系对所呈现的数据进行了讨论。
