Department of Botany, Panjab University, Chandigarh 160 014, India.
Department of Environment Studies, Panjab University, Chandigarh 160 014, India.
Molecules. 2021 Sep 2;26(17):5347. doi: 10.3390/molecules26175347.
Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed (Asteraceae). It accounts for a multitude of biological activities, including toxicity, allergenicity, allelopathy, and pharmacological aspects of the plant. Thus far, parthenin and its derivatives have been tested for chemotherapeutic abilities, medicinal properties, and herbicidal/pesticidal activities. However, due to the lack of toxicity-bioactivity relationship studies, the versatile properties of parthenin are relatively less utilised. The possibility of exploiting parthenin in different scientific fields (e.g., chemistry, medicine, and agriculture) makes it a subject of analytical discussion. The present review highlights the multifaceted uses of parthenin, on-going research, constraints in the practical applicability, and the possible workarounds for its successful utilisation. The main aim of this comprehensive discussion is to bring parthenin to the attention of researchers, pharmacologists, natural product chemists, and chemical biologists and to open the door for its multidimensional applications.
小白菊内酯型倍半萜内酯角蒿素是热带杂草（菊科）的代表性次生代谢物。它具有多种生物活性，包括毒性、变应原性、化感作用和植物的药理学方面。到目前为止，角蒿素及其衍生物已被测试用于化疗能力、药用特性和除草/杀虫剂活性。然而，由于缺乏毒性-生物活性关系研究，角蒿素的多功能特性的利用相对较少。角蒿素在不同科学领域（例如化学、医学和农业）的应用潜力使其成为分析讨论的主题。本综述重点介绍了角蒿素的多方面用途、正在进行的研究、实际应用的限制以及成功利用的可能解决方案。本次全面讨论的主要目的是引起研究人员、药理学家、天然产物化学家以及化学生物学家对角蒿素的关注，并为其多维应用开辟道路。
