Pedras M S, Khan A Q
Department of Chemistry, University of Saskatchewan, Saskatoon SK, Canada.
Phytochemistry. 2000 Jan;53(1):59-69. doi: 10.1016/s0031-9422(99)00479-3.
The unusual metabolism of the cruciferous phytoalexin camalexin by virulent and weakly virulent isolates of the root rot fungus Rhizoctonia solani Kuhn is reported. This biotransformation proceeded via 5-hydroxycamalexin, which was further biotransformed into more polar metabolites. Importantly, the metabolites resulting from transformation of camalexin were significantly less toxic to the pathogen than camalexin. Thus, it was concluded that R. solani can detoxify camalexin through oxidation of the indole ring. The chemistry involved in the structure determination of the intermediates of this pathway, their synthesis as well as antifungal activity is described.
据报道，根腐病菌立枯丝核菌（Rhizoctonia solani Kuhn）的强毒和弱毒分离株对十字花科植物抗毒素camalexin具有不同寻常的代谢作用。这种生物转化通过5-羟基camalexin进行，5-羟基camalexin进一步被生物转化为极性更强的代谢产物。重要的是，camalexin转化产生的代谢产物对病原体的毒性明显低于camalexin。因此，得出结论：立枯丝核菌可通过吲哚环氧化作用使camalexin解毒。本文描述了该途径中间体结构测定、合成及其抗真菌活性所涉及的化学过程。
