尿液中茚地那韦结晶的检测：取决于分析方法。

Detection of indinavir crystals in urine: dependence on method of analysis.

作者信息

Hortin G L, King C, Miller K D, Kopp J B

机构信息

Clinical Pathology Department, Warren Grant Magnusson Clinical Center, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

出版信息

Arch Pathol Lab Med. 2000 Feb;124(2):246-50. doi: 10.5858/2000-124-0246-DOICIU.

DOI:10.5858/2000-124-0246-DOICIU

PMID:10656734

Abstract

OBJECTIVES

To determine the frequency of crystalluria in patients treated with the human immunodeficiency virus protease inhibitor indinavir and to compare methods of detecting crystalluria.

METHODS

A total of 308 freshly voided urine specimens from 168 patients treated with indinavir were evaluated by manual microscopy of sediment and microscopy with an automated workstation and by dipstick analysis.

RESULTS

Crystals were detected in 22%, 31%, or 32% of specimens using, respectively, an automated workstation, manual microscopy, or both methods. Proteinuria or hemoglobinuria occurred significantly more often in specimens with (28%) than without (18%) crystals. Frequency of crystalluria was unrelated to specific gravity, but it increased at higher pH. Crystals were detected in 21% of specimens with pH less than 6 and 42% of specimens with pH of 6 or higher.

CONCLUSIONS

Crystalluria occurs in more than 30% of urine specimens from patients treated with indinavir, but detection rates vary substantially with method of analysis. Manual microscopy detected crystalluria 41% more often than did an automated workstation.

摘要

目的

确定接受人类免疫缺陷病毒蛋白酶抑制剂茚地那韦治疗的患者中结晶尿的发生率，并比较检测结晶尿的方法。

方法

对168例接受茚地那韦治疗患者的308份新鲜晨尿标本进行评估，采用尿沉渣手工显微镜检查、自动工作站显微镜检查及试纸条分析。

结果

分别使用自动工作站、手工显微镜检查或两种方法，在22%、31%或32%的标本中检测到晶体。有晶体的标本（28%）中蛋白尿或血红蛋白尿的发生率显著高于无晶体的标本（18%）。结晶尿的发生率与比重无关，但在较高pH值时增加。在pH值小于6的标本中，21%检测到晶体，在pH值为6或更高的标本中，42%检测到晶体。