Göhler L, Hahnemann T, Michael N, Oehme P, Steglich H D, Conradi E, Grune T, Siems W G
Clinics of Physical Medicine and Rehabilitation, University Hospital Charité, Humboldt University, Berlin, Germany.
Prev Med. 2000 Feb;30(2):95-102. doi: 10.1006/pmed.1999.0602.
Sympathetic hyperactivity is one factor for alterations encountered in the plurimetabolic syndrome, a cluster of metabolic abnormalities including obesity, hyperlipidemia, sometimes hyperglycaemia, and hypertonia. It was interesting to know if prolonged severe underfeeding (230 kcal/day) leads to decreases in catecholamines in those patients.
The plasma concentrations of catecholamines in patients (n = 16) suffering from plurimetabolic syndrome were studied before and during a 16-day period of medically controlled severe underfeeding (230 kcal/day) at rest and in response to exercise.
During the period of underfeeding, mean norepinephrine concentrations decreased at rest from 1.45 to 0. 96 nmol/liter, and in response to exercise, from 6.1 to 3.2 nmol/liter. Epinephrine concentrations decreased from 0.15 to 0.1 nmol/liter and from 0.26 to 0.17 nmol/liter, respectively. A significant decrease in catecholamine concentrations was observed only after 16 days of underfeeding.
Clinically controlled underfeeding of patients with plurimetabolic syndrome may result in beneficial clinical and biochemical effects. The findings indicate that relatively long periods of underfeeding induce decreases in plasma catecholamine concentrations. Nevertheless, most of the fall in mean values in norepinephrine and also of the fall in blood pressure values occurred by Day 2. From those tendencies and from the significant changes in both parameters at Day 16 of severe underfeeding one could conclude that altered sympathetic nervous system activity could contribute to the fall in blood pressure.
交感神经过度活跃是多代谢综合征中出现的改变的一个因素，多代谢综合征是一组代谢异常，包括肥胖、高脂血症，有时还有高血糖和高血压。了解长期严重摄入不足（每天230千卡）是否会导致这些患者儿茶酚胺水平下降很有意思。
对16例患有多代谢综合征的患者，在医学控制的严重摄入不足（每天230千卡）的16天期间，于静息状态及运动时，研究其血浆儿茶酚胺浓度。
在摄入不足期间，静息时平均去甲肾上腺素浓度从1.45纳摩尔/升降至0.96纳摩尔/升，运动时从6.1纳摩尔/升降至3.2纳摩尔/升。肾上腺素浓度分别从0.15纳摩尔/升降至0.1纳摩尔/升，从0.26纳摩尔/升降至0.17纳摩尔/升。仅在摄入不足16天后观察到儿茶酚胺浓度显著下降。
对多代谢综合征患者进行临床控制的摄入不足可能会产生有益的临床和生化效果。研究结果表明，相对较长时间的摄入不足会导致血浆儿茶酚胺浓度下降。然而，去甲肾上腺素平均值的大部分下降以及血压值的下降在第2天就已出现。从这些趋势以及严重摄入不足第16天时这两个参数的显著变化可以得出结论，交感神经系统活动的改变可能导致血压下降。
