Mellersh C S, Hitte C, Richman M, Vignaux F, Priat C, Jouquand S, Werner P, André C, DeRose S, Patterson D F, Ostrander E A, Galibert F
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
Mamm Genome. 2000 Feb;11(2):120-30. doi: 10.1007/s003350010024.
Purebred dogs are a unique resource for dissecting the molecular basis of simple and complex genetic diseases and traits. As a result of strong selection for physical and behavioral characteristics among the 300 established breeds, modern dogs are characterized by high levels of interbreed variation, complemented by significant intrabreed homogeneity. A high-resolution map of the canine genome is necessary to exploit the mapping power of this unusual resource. We describe here the integration of an expanded canine radiation hybrid map, comprised of 600 markers, with the latest linkage map of 341 markers, to generate a map of 724 markers-the densest map of the canine genome described to date. Through the inclusion of 217 markers on both the linkage and RH maps, the 77 RH groups are reduced to 44 syntenic groups, thus providing comprehensive coverage of most of the canine genome.
纯种狗是剖析简单和复杂遗传疾病及性状分子基础的独特资源。在300个已确立的犬种中，由于对身体和行为特征进行了强烈选择，现代犬种的特点是品种间差异大，同时品种内高度同质。要利用这一独特资源的定位能力，需要一张高分辨率的犬类基因组图谱。我们在此描述了由600个标记组成的扩展犬辐射杂种图谱与包含341个标记的最新连锁图谱的整合，以生成一张包含724个标记的图谱——这是迄今为止所描述的最密集的犬类基因组图谱。通过在连锁图谱和辐射杂种图谱上都纳入217个标记，77个辐射杂种组减少到44个同线组，从而全面覆盖了大部分犬类基因组。
