Bruce M C, Donnelly C A, Alpers M P, Galinski M R, Barnwell J W, Walliker D, Day K P
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3FY, UK.
Science. 2000 Feb 4;287(5454):845-8. doi: 10.1126/science.287.5454.845.
The dynamics of multiple Plasmodium infections in asymptomatic children living under intense malaria transmission pressure provide evidence for a density-dependent regulation that transcends species as well as genotype. This regulation, in combination with species- and genotype-specific immune responses, results in nonindependent, sequential episodes of infection with each species.
在疟疾传播压力巨大地区生活的无症状儿童中，多种疟原虫感染的动态变化为一种超越物种及基因型的密度依赖性调节提供了证据。这种调节与物种和基因型特异性免疫反应相结合，导致每种疟原虫的感染呈现非独立的、相继发生的情况。
