Bruce M C, Donnelly C A, Packer M, Lagog M, Gibson N, Narara A, Walliker D, Alpers M P, Day K P
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford.
Parasitology. 2000 Sep;121 ( Pt 3):247-56. doi: 10.1017/s0031182099006344.
The burden and duration of asymptomatic malaria infections were measured in residents of the malaria endemic village of Gonoa, Madang Province, Papua New Guinea. Plasmodium falciparum, P. vivax and P. malariae infections in people aged 4 years to adulthood were compared. Frequent sampling at 3-day intervals for up to 61 days allowed assessment of individual episodes of infection. Statistical assessment of P. falciparum detection revealed a periodicity consistent with synchronous replication of this species over periods up to 27 days. The duration of P. falciparum episodes was longer across all age groups than that of P. vivax and P. malariae. A trend for decreasing duration with age was also noted in data from each species. This was most prominent in P. falciparum infections: median duration in 4-year-olds was > 48 days compared with a median between 9 and 15 days in older children and adults. The results are consistent with the slow acquisition of immunity to antigenically diverse Plasmodium populations and suggest a faster rate of acquisition to P. vivax and P. malariae than to P. falciparum.
在巴布亚新几内亚马当省戈诺亚疟疾流行村庄的居民中，对无症状疟疾感染的负担和持续时间进行了测量。比较了4岁至成年人群中恶性疟原虫、间日疟原虫和三日疟原虫的感染情况。每隔3天进行一次频繁采样，持续61天，以便评估个体感染发作情况。对恶性疟原虫检测的统计评估显示，在长达27天的时间段内，该物种的周期性与同步复制一致。在所有年龄组中，恶性疟原虫发作的持续时间比间日疟原虫和三日疟原虫更长。在每个物种的数据中也注意到发作持续时间随年龄增长而减少的趋势。这在恶性疟原虫感染中最为明显：4岁儿童的中位持续时间>48天，而大龄儿童和成年人的中位持续时间在9至15天之间。这些结果与对抗抗原性多样的疟原虫群体免疫力缓慢获得一致，并表明对间日疟原虫和三日疟原虫的获得速度比对恶性疟原虫更快。
