Lindh C, Liu Z, Welin M, Ordeberg G, Nyberg F
Department of Orthopedics, University Hospital, Uppsala, Sweden.
Neuropeptides. 1999 Dec;33(6):517-21. doi: 10.1054/npep.1999.0772.
Cerebrospinal fluid (CSF) levels of calcitonin gene-related peptide-like activity (CGRP-LI), were determined in 35 patients with painful orthopaedic disorders and the activity was compared to that of 12 healthy controls without pain. Fourteen patients had pain from osteoarthritis of the hip or the knee, 11 had rhizopathic pain due to a herniated lumbar disc and 10 had pain from a hip fracture. In all patients, decreased CGRP-LI was observed in CSF compared to the controls. The lowest values were found in the patients with osteoarthritis, while there was less, but still significant, reduction of CGRP-LI in the patients with herniated lumbar disc and those with a hip fracture. In most of the patients, CGRP-LI was also analysed at a second lumbar puncture after operative treatment, when pain had subsided or was reduced. However, the CGRP-LI remained low after treatment, which may suggest the influence of factors other than pain.
测定了35例患有疼痛性骨科疾病患者脑脊液（CSF）中降钙素基因相关肽样活性（CGRP-LI）水平，并将其活性与12名无疼痛的健康对照者进行比较。14例患者因髋或膝关节骨关节炎疼痛，11例因腰椎间盘突出症引起神经根性疼痛，10例因髋部骨折疼痛。与对照组相比，所有患者脑脊液中CGRP-LI均降低。骨关节炎患者的值最低，而腰椎间盘突出症患者和髋部骨折患者的CGRP-LI降低程度较小，但仍有显著差异。在大多数患者中，手术治疗后疼痛减轻或缓解时，在第二次腰椎穿刺时也分析了CGRP-LI。然而，治疗后CGRP-LI仍保持较低水平，这可能表明存在疼痛以外因素的影响。
