Lindh C, Liu Z, Lyrenäs S, Ordeberg G, Nyberg F
Department of Orthopaedics, University Hospital, Uppsala, Sweden.
Scand J Rheumatol. 1997;26(6):468-72. doi: 10.3109/03009749709065721.
Cerebrospinal fluid (CSF) levels of substance P like immunoreactivity (SPLI) were determined in 11 patients with painful osteoarthritis in hip or knee, 9 patients with rhizopatic pain from a herniated lumbar disc, and in 9 healthy volunteers without pain. The patients with osteoarthritis had increased levels of SPLI in CSF (p < 0.001) compared to the controls. A positive correlation was also seen between the CSF SPLI and the degree of pain. At a second lumbar puncture 5 months after operation, SPLI had decreased, but was still significantly higher than in the controls. No difference in CSF SPLI was seen in the patients with herniated lumbar disc compared to the controls, neither before treatment, nor at follow up CSF postoperatively. The results suggest that nociceptive joint pain is consistent with increased SPLI in CSF. Differences in SPLI in CSF may be useful to differentiate pain from various origin, and may also increase our understanding of different pain mechanisms.
对11例髋部或膝部疼痛性骨关节炎患者、9例因腰椎间盘突出症导致神经根性疼痛的患者以及9名无疼痛的健康志愿者测定了脑脊液（CSF）中P物质样免疫反应性（SPLI）水平。与对照组相比，骨关节炎患者脑脊液中SPLI水平升高（p < 0.001）。脑脊液SPLI与疼痛程度之间也呈正相关。术后5个月第二次腰椎穿刺时，SPLI有所下降，但仍显著高于对照组。与对照组相比，腰椎间盘突出症患者在治疗前及术后随访脑脊液时，脑脊液SPLI均无差异。结果表明，伤害感受性关节疼痛与脑脊液中SPLI升高一致。脑脊液中SPLI的差异可能有助于区分不同来源的疼痛，也可能增进我们对不同疼痛机制的理解。
