Vescovi P P, Pezzarossa A
Center of Alcohology, University of Parma, Parma, Italy.
Neuropeptides. 1999 Dec;33(6):522-5. doi: 10.1054/npep.1999.0773.
During cocaine addiction the hypothalamus-pituitary axis is widely affected and a blunted response of thyroid stimulating hormone (TSH) to thyroid releasing hormone (TRH) consistent with a hyperthyroid state has been observed. Since the thyroid status can affect the release of growth hormone (GH) the authors evaluated TSH and GH responses to TRH in cocaine addicts at the time of drug withdrawal and 30 days after. Twenty-six male cocaine addicts and 11 healthy male control subjects agreed to participate in the study. TRH and placebo tests were performed at random at 5 day intervals at the time of drug withdrawal and after 30 days. In drug addicts, at the time of the first test basal plasma levels of freeT3, freeT4 and TSH were normal, but the TSH response to TRH was impaired. After 30 days of cocaine abstinence basal freeT4 plasma levels were significantly lower, and TSH levels and the TSH response to TRH were higher than in the first test. At the first examination, basal GH concentrations were similar in cocaine addicts and in control subjects and GH did not respond to TRH. After 30 days of abstinence, basal GH plasma levels were unmodified, but the TRH became stimulatory of GH release in cocaine-deprived, but not in control subjects. In conclusion, in cocaine addicts, drug withdrawal is associated with a condition of subclinical hypothyroidism that makes the GH-releasing machinery sensitive to TRH.
在可卡因成瘾期间，下丘脑 - 垂体轴受到广泛影响，并且观察到促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应迟钝，这与甲状腺功能亢进状态一致。由于甲状腺状态可影响生长激素（GH）的释放，作者评估了可卡因成瘾者在戒毒时及戒毒30天后TSH和GH对TRH的反应。26名男性可卡因成瘾者和11名健康男性对照受试者同意参与该研究。在戒毒时及30天后，每隔5天随机进行TRH和安慰剂测试。在吸毒者中，首次测试时游离T3、游离T4和TSH的基础血浆水平正常，但TSH对TRH的反应受损。戒毒30天后，基础游离T4血浆水平显著降低，TSH水平以及TSH对TRH的反应高于首次测试。在首次检查时，可卡因成瘾者和对照受试者的基础GH浓度相似，且GH对TRH无反应。戒毒30天后，基础GH血浆水平未改变，但TRH在可卡因戒断者中刺激了GH释放，而在对照受试者中则未刺激。总之，在可卡因成瘾者中，戒毒与亚临床甲状腺功能减退状态相关，这使得GH释放机制对TRH敏感。
