Johansson B, Ingvarsson S, Björck P, Borrebaeck C A
Department of Immunotechnology, Lund University, Lund, Sweden.
J Immunol. 2000 Feb 15;164(4):1847-54. doi: 10.4049/jimmunol.164.4.1847.
Interdigitating dendritic cells (IDC) represent a mature progeny of dendritic cells (DC) in vivo and are exhibiting a strong lymphocyte stimulatory potential. Because of the restricted localization to secondary lymphoid organs where decisive cellular interactions take place in the initial events of immunity, IDC regulatory function was addressed in relation to naive B cells. In this study, we demonstrate that human tonsillar IDC induce a dual response from CD40-activated IgD+/CD38- naive B lymphocytes. IDC direct naive B cells toward either isotype switching or an IL-13-dependent IgM secretion. IDC-dependent proliferation, isotype switching, and Ig production are all strictly mediated by soluble factors, suggesting that such skewing in B cell activation is the result of differential cytokine expression. Moreover, IDC-expressed IL-13 represents a novel source of a cytokine with recently established effects in Th2 induction as well as in immunological disorders resulting in allergic reactions.
交错突细胞（IDC）是体内树突状细胞（DC）的成熟后代，具有强大的淋巴细胞刺激潜能。由于其局限于次级淋巴器官，而免疫初始事件中决定性的细胞相互作用在此发生，因此针对幼稚B细胞研究了IDC的调节功能。在本研究中，我们证明人扁桃体IDC可诱导CD40激活的IgD+/CD38-幼稚B淋巴细胞产生双重反应。IDC引导幼稚B细胞进行同种型转换或依赖白细胞介素-13（IL-13）的IgM分泌。依赖IDC的增殖、同种型转换和Ig产生均严格由可溶性因子介导，这表明B细胞激活中的这种偏向是细胞因子差异表达的结果。此外，IDC表达的IL-13代表了一种细胞因子的新来源，该细胞因子最近已被证实对Th2诱导以及导致过敏反应的免疫紊乱有作用。
