Juan G M, Kawamura S, Yasui N, Yoshida Y
Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-Akita.
Neurol Med Chir (Tokyo). 1999 Dec;39(13):908-11; discussion 912. doi: 10.2176/nmc.39.908.
Histological changes in and around the arterial walls of rats were investigated following simultaneous topical application of cotton sheet and cyanoacrylate glue. The bilateral common carotid arteries were exposed using sterile techniques, and the test materials were applied to the right artery. The left artery served as a control. Changes in arterial histology were evaluated at 2 weeks, 1 month, 2 months, and 3 months after surgery. Extensive inflammation consisting primarily of histiocytes and multinuclear giant cells was observed around the materials, but tended to decrease by 3 months. Necrosis in the media and fibrosis in the adventitia initially appeared around 2 weeks, and became advanced by 2-3 months. At 2-3 months, disruption of elastic fibers and marked fibrosis in the media were seen, and endothelial proliferation in the intima appeared. Intimal proliferation was observed at both the experimental and other sites of the vessels. The present results suggest that simultaneous use of the test materials can cause the arterial occlusive lesions observed following aneurysmal surgery.
在大鼠动脉壁及其周围同时局部应用棉片和氰基丙烯酸酯胶后，对其组织学变化进行了研究。采用无菌技术暴露双侧颈总动脉，将测试材料应用于右侧动脉。左侧动脉作为对照。在术后2周、1个月、2个月和3个月评估动脉组织学变化。在材料周围观察到主要由组织细胞和多核巨细胞组成的广泛炎症，但在3个月时趋于减轻。中膜坏死和外膜纤维化最初在2周左右出现，并在2 - 3个月时加重。在2 - 3个月时，可见弹性纤维破坏和中膜明显纤维化，内膜出现内皮细胞增殖。在实验血管部位及其他血管部位均观察到内膜增殖。目前的结果表明，同时使用测试材料可导致动脉瘤手术后观察到的动脉闭塞性病变。
