Herrera O, Kawamura S, Yasui N, Yoshida Y
Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-Akita.
Neurol Med Chir (Tokyo). 1999 Feb;39(2):134-9; discussion 139-40. doi: 10.2176/nmc.39.134.
Histological changes in and around the arterial walls of rats were investigated following topical application of aneurysmal wrapping and coating materials, including a fibrin glue, a cyanoacrylate glue (Biobond), and cotton fibers (Bemsheet). Bilateral common carotid arteries were exposed using sterile techniques, and one of the test materials was applied to the right artery. The left artery was used as the control. Changes in arterial histology were evaluated at 2 weeks, 1 month, 2 months, and 3 months after surgery. The fibrin glue was surrounded by intense inflammation at 2 weeks after surgery. Both the fibrin glue and inflammation had disappeared at 2 months, but the glue had induced mild inflammation in the adventitia. Biobond caused chronic inflammation, necrosis of the media, and thickening of the arterial wall due to fibrosis in both the media and adventitia. Bemsheet produced chronic inflammation, progressive fibrosis, and granuloma. Connective tissue increased in the adventitia, but no major changes were observed in the media. The Bemsheet fibers remained unchanged, and adhered to the arterial wall. Although arterial stenoses were not observed in the present study, the results suggest that cyanoacrylate glue can cause the arterial occlusive lesions observed following aneurysm surgery.
在局部应用包括纤维蛋白胶、氰基丙烯酸酯胶（生物胶）和棉纤维（贝姆片）在内的动脉瘤包裹和涂层材料后，研究大鼠动脉壁及其周围的组织学变化。采用无菌技术暴露双侧颈总动脉，将一种测试材料应用于右侧动脉。左侧动脉用作对照。在手术后2周、1个月、2个月和3个月评估动脉组织学变化。术后2周，纤维蛋白胶周围出现强烈炎症。2个月时，纤维蛋白胶和炎症均消失，但该胶水在外膜引起了轻度炎症。生物胶导致慢性炎症、中膜坏死以及由于中膜和外膜纤维化而导致动脉壁增厚。贝姆片产生慢性炎症、进行性纤维化和肉芽肿。外膜中的结缔组织增加，但中膜未观察到重大变化。贝姆片纤维保持不变，并附着于动脉壁。尽管在本研究中未观察到动脉狭窄，但结果表明氰基丙烯酸酯胶可导致动脉瘤手术后观察到的动脉闭塞性病变。
